Ιntegrated External and Internal Exposure Modelling Platform (INTEGRA) / Funded by the European Chemical Industry Council (CEFIC)
The scope of the project proposal was to develop an integrated methodology, based on modelling of fate, transport and toxicokinetics, to determine better estimates of internal exposure of different populations over the life-cycle of a substance. The results should be validated against available results of reliable HBM studies. In a first Tier the approach could be applied on exposure at the workplace for substances for which biological monitoring results as well as external exposure data are available, preferably by inhalation and through the skin. The contribution of different routes of exposure to the total body burden should be evaluated as well and if possible related to physical and chemical properties of substances. The second Tier should consider secondary exposure of humans in particular to persistent chemicals. Existing HBM data in human plasma and breast milk could be evaluated using comparison with integrated model predictions, possibly by a combination of advanced environmental fate modelling and PBTK calculations.